“Primary ciliary dyskinesia is a genetically heterogeneous autosomal-recessive disorder with an incidence of 1:15,000 live births. This disorder affects the proper biogenesis, assembly and activity of cilia, resulting in dysfunction of motile cilia and impairment of MCC. The clinical features include situs inversus in 50% of the patients, infertility, and chronic ear infections. The disease affects the entire respiratory tract, with symptoms appearing soon after birth. Over 80% of PCD patients experience neonatal respiratory distress during the first 24 h of life (Shapiro et al. 2016). Because of impaired MCC, mucus and pathogens accumulate in the upper and lower airways causing year-round daily cough and nasal congestion, chronic sinusitis, and recurrent lower respiratory infections, leading to bronchiectasis, and, in severe cases, lung transplantation.” ~ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378048/#!po=53.9474
The more you know…
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